The bridge is close to the Brooklyn neighborhood where Vincent Mancini lived in the 1970s.
In the video game
In the video game, when Vito Corleone is shot, his attackers attempt to ambush his ambulance by forcing it onto the bridge. The Tattaglia Capo in charge of the attack engages in a firefight with Aldo Trapani which he loses, and is forced to reveal the location of consigliere Tom Hagen before expiring.
The Brooklyn Bridge can be seen from a street near La Maison Rouge in The Godfather Game 2.